Unless our patients were hoarding casks of vintage Fireball Whiskey, the cases presented are likely tragic stories of the toll that chronic addiction takes on its victims, not key pieces of evidence of propylene glycol toxicity. Overall, propylene glycol is "generally considered to be a safe chemical," according to the Agency for Toxic Substances and Disease . Purity of 99.8% and above is permissible. Like ethylene glycol, it is also considered not safe for human ingestion. It is in anywhere from 26.4% to 37.8% of registered personal care products. In ice cream, for example, its used to help inhibit the formation of those unwanted ice crystals you see after putting the carton back in the freezer. Googled it to see whats so harmful about it and here found the Material Safety Data Sheet warns users to avoid skin contact with propylene glycol as this strong skin irritant can cause liver abnormalities and kidney damage. Since its 25mg (and not 25g), shouldnt it be 0,003 pounds? Decreasing the viscosity of a formulation makes the product more spreadable when applied to the skin or hair. . Polyethylene glycol, or PEG, sounds similar enough to the toxic ethylene glycol to easily confuse the two; however, the key difference is in the poly- portion of the name. (BTW, the testing is done on people, not animals.) Dow's DPG is utilized as a solvent, coupling agent and chemical intermediate in numerous industries, having a wide range of . Dipropylene Glycol. I would love for more clear labelling and more products that are PG-free, not because Im afraid it will give me cancer, but because it promotes a strong burning, inflamed, scaling situation on my face :s Oddly this reaction if often most severe when I use products specifically advertised as being formulated for sensitive skin, that contain PG. It is in so many things, foods, cosmetics, even the medication- all this time and the ointments we were putting on her to treat eczema had the very ingredient she was allergic to. Is propylene glycol cancerous? That makes sense since burned skin would be missing the outer protective layer. A glycol, by definition, is any compound in the alcohol family with two -OH groups. Lets get into the basics of finasteride for hair loss and how the prescription medication stacks up to ProCelinyl, a breakthrough ingredient that is fundamentally changing the hair loss industry. Be sure to pay close attention to product labels the . Was there contamination in a certain batch? It also has uses in cosmetics, and commercial fog fluid. By American standards, that batch of Fireball Whiskey was perfectly fine. For this reason, a variety of laws have been passed within the last 20 years mandating that bittering agents be added to commercial antifreeze, with American manufacturers voluntarily adding the bittering agent as of 2012. Dipropylene Glycol LO+ (DPG LO+) is a high-purity product, designed for use in odor-sensitive applications such as fragrances and cosmetics. Were all predisposed to respond more strongly to negative information and fearmongering can be a profitable sales tactic that uses our human nature against us. In this article, which isa unique case rather than a standalone publication or investigation, two middle-aged patients with a history of alcohol abuse reported to the emergency room with acute lactic acidosis. NIOSH S69 (II-2) , 2554 . Historically, ethylene glycolnot propylene glycolhad been widely used as the main additive in antifreeze, and its slightly sweet taste made it attractive to animals. Let's take a deep dive in this blog. The FDA declared the ingredient to be GRAS (generally regarded as safe) and it is frequently used in food products without harm to the vast majority of people. 1 0 obj Who is it for? For a 130 pound person that would be about 0.11 ouncesof PG per day before you might have problems. Dipropylene glycol also functions as a masking agent in cosmetics and personal care products. According to the FDA (Food and Drug Administration), it is used as an additive that is generally safe to add in food. Impaired liver functioning with increased alcohol consumption would lead to lactic acid accumulation. In the case of the latter patient, his blood had acidified to a pH of 6.94, well below the typical range around 7.4. Because of propylene glycols use as a nontoxic alternative to ethylene glycola similar, more hazardous compoundin commercial antifreeze, the chemical itself has now become almost synonymous with antifreeze itself. Why? <>/Metadata 979 0 R/ViewerPreferences 980 0 R>> Dipropylene Glycol is a common ingredient in shampoos, conditioners, and styling products. Its a mixture thats named for the job it does: keeping things from freezing. As a solvent, dipropylene glycol helps to dissolve or suspend other ingredients in a formulation without altering the other ingredients. His additional symptomsand they were legionincluded hypothermia, elevated heart rate, elevated respiratory rate, and a blood oxygen level of 54%. In perspective, let's say I pulled two red M&Ms out of a bag and concluded that the bag contained, What is lactic acid? Were going to guess no. When it comes to creating that niche though, differentiation often boils down to a question of style versus substance. I really love your website , Very interesting article, thanks for explaining! -Clients with sensitive skin should not use products like serum and toners with OH in the first 6 ingredients listed. Propylene glycol is a colorless, nearly odorless, thick liquid. A masking agent is used to disguise the natural smell of the active ingredients, especially those that have an unpleasant smell. First, lets clarify: Antifreeze is a functional name. I am tamilnadu and my age 35 years . (function(d, s, id) { "Those sound like good things!" var isSSL = 'https:' == document.location.protocol; Best of all, its labeled by the FDA as. All skin types except those that have an identified allergy to it. There are many different types of compounds that belong to this family, such as butylene glycol, polyethylene glycol, ethylene glycol, and more. This helps preserve the products. Is polyethylene glycol safe for skin? Propylene and butylene glycol are both humectant moisturisers. Propylene and butylene glycol are also commonly used in products as solvents. Were used to nutrients and pharmaceuticals, but what are nutraceuticals, exactly? medianet_height = "90"; This work was published in 1994. https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/PR560.PDF. 1gram=1000mg Dipropylene Glycol Fragrance Safety Data Sheet Date issued: 02/03/2022 Date of revision: Revision No. In cosmetics and skincare products, dipropylene glycol functions as a solvent, viscosity-decreasing agent, masking agent, and fragrance ingredient. The point is: many chemicals can fill many different roles, but some are better than others for a certain task. Episode 54. Who is it for? It is a solvent used in paints, pastes, dyes, resins, brake fluids and inks, and in making cosmetics. The safety of dipropylene glycol and other glycols has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel, a group responsible for evaluating the safety of skincare and cosmetic ingredients. You might even learn that glycols are found in antifreeze. Propylene glycol is safe in small doses. Propylene glycol is a safe ingredient as long as it does not irritate or place discomfort on your skin. 2.5g per lb is 325gm, about 11.6 ounces. medianet_width = "728"; Repeated exposure to very high levels may affect the liver. Next post: Why is Gold Bond lotion good enough for stylists? Previous post: Is lead in lipstick dangerous? . The glycols produced mild to severe ocular irritation with Hexylene Glycol producing the most severe irritation. Propylene glycol is popular for moisturizing and smoothening the skin ( 1 ). Wow your site and podcasts are so informative and scientifically correct! Dear!!! The material, a distilled product with purity greater than 99.5% as dipropylene glycol, is a liquid that is practically odorless, colorless, water-soluble and hygroscopic that is its advantage in perfumery . water). Propylene glycol is used in many products, so why mention antifreeze, completely out of context? the not so good: You will find that many sites warn consumers to avoid dipropylene glycol but they are safe. A few percent or less of PG can prevent a cream or lotion from developing a grainy, cottage cheese-like texture when exposed to low temperatures. Your IP: Experts consider butylene glycol safe for use in skin care and cosmetics. The other 0.2% of miscellaneous may not seem like much, until you hear how much is being used in food. Propylene glycol is a versatile substance that carries out many functions in the product formulations in which it is included. For example, according to the website The Good Human the main role of PG is to help any other chemicals that you come in contact with reach your bloodstream. and that it alters the structure of the skin by allowing chemicals to penetrate deep beneath it while increasing their ability to reach the blood stream. Take this quote, Creating a common enemy in propylene glycol generates, an implicit contrast between mainstream consumer goods and positions products being pushed by other up-and-coming companies as outside alternatives, a strategy weve, . It secures the water and takes it to the outer layer of your skin. Besides a unique flavor profile, the cinnamon-flavored liquor contains a compound you should be familiar with by now: propylene glycol! When the respiratory system is depressed, our breathing becomes shallower, meaning we get progressively less and less oxygenyou might see how lactic acidosis could spiral out of control in certain cases. 8 Final Report on the Safety Assessment of Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol, International Journal of Toxicology. ( 1) Another name for it is "propane-1,2-diol," which is sometimes used when listing it as a . First, its highly dangerous to rely on an article with a sample size of two! Given their size and the types of bonds involved in their linkage, polymers can be difficult for humans to digestin this case, polyethylene glycol is actually considered to be biologically inert, meaning that it wont react with living tissue when it comes in contact with it. 3417 Reviews. Thank you for a simple and in depth overview, there are so many conflicting bits of information on so many things and I always wonder why there are so many direct opposites. Now its all clear as a sun You guys are the best! Despite being completely safe, nontoxic, and useful, propylene glycol has simply fallen prey to fearmongering marketing strategieslets break down how it happened. How would pg relate to a spray tannin product? Thank you. Products with this ingredient are allowed for use in EWG VERIFIED . It is a colorless, odorless liquid that is completely water-soluble. -if I do a peel on a client, products with higher concentrations of PG are NOT good in my protocol post peel. It is unfortunate that you have had a reaction to PG. That hasnt stopped the media and other outlets from capitalizing on this fear though. Though the two chemicals sound quite similar, from a structural standpoint, theyre quite different! Save. Cream is oil based so it has manuka oil and manuka honey, both great ingredients for soothing and healing irritated skin. Cloudflare Ray ID: 766f60464c666909 Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. It is the industry standard, non-toxic and safe on the skin. To be fair, I should also point out that PG is used at higher concentrations in a few products where it acts as a solvent for other ingredients. Its also the main ingredient in antifreeze. In fact, a few published articlesand both published and articles are really pushing the definitions of those terms purportedly documented acute toxicity from consuming Fireball Whiskey. It is a preservative: Due to its antibacterial qualities, which help inhibit the proliferation of germs, propylene glycol may help extend the shelf life of cosmetic products and keeps the goods fresh. Polyethylene glycol has been rated a low hazard ingredient in skincare products 3 and is safe to use on our skin. References:CIR, 1985. I think this scare story is one that actually got into cosmetics from pharmaceuticals, which is an unusual source. So when it comes to propylene glycol, theres a lot of smoke and mirrors, but no real fire. Take this quotefor instance: The science can be murky, but we avoid the clear offenders. Keep an eye on: Nothing to keep an eye on here. This is true, but the glycol that is used in antifreeze is different from dipropylene glycol. Nope! Subjects: . What does dipropylene glycol do to your skin? It is mainly used as a solvent, viscosity-decreasing agent, masking agent, and fragrance ingredient. Butylene Glycol . The fact that China and neighboring countries are large producers of it probably doesn't add to your confidence in its purity! }(document, "script", "aweber-wjs-128tge0y5")); medianet_width='336'; medianet_height= '280'; medianet_crid='757532408'; https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/PR560.PDF. my face is normal colour but my hand is black what is my problem i dont no i am seeing in your treatment quire my problem and pls tell how to use glycol. Study type: Cumulative 14-day skin irritation test with dipropylene glycol (100% and 50% solution in water) in human volunteers. However, there . in our everyday lives, including cosmetics, food, and personal care product. Thats why propylene glycol has taken ethylene glycols place in many blends of consumer antifreeze, where its actually labeled as a nontoxic alternative. According to the US Food & Drug Administration, propylene glycol is Generally Recognized As Safe (GRAS) for direct addition to food. no nicotine flavors. Wow,that was a huge math mistake but its been fixed now. Read on as we pull back the curtain on the hair loss industry. Odor: characteristic. var mnSrc = (isSSL ? Its a mixture thats named for the job it does: keeping things from freezing. The skin penetration angle is obviously a bigger worry in a product with a serious medical active in it. Do you have a link to a study indicating that? This Cleansing Oil Gel is a highly transparent oil cleansing gel with thixotropic properties. Scientific Facts: Butylene Glycol, or 1,3-Butanediol, dissolves most essential oils and synthetic flavoring substances. This exacerbates the original issue of acute lactic acidosis, and the patients condition can accelerate downhill. Propylene glycol acts as a humectant at a low concentration level. Signs you have a propylene glycol allergy. Clinical tests have determined that the glycols produce mild to severe irritation to the eyes. Dipropylene Glycol Methyl Ether is a colorless liquid with a mild and pleasant odor. 855328 4 - aqua/water, glycerin, propylene glycol, butylene glycol, potassium phosphate, polysorbate 80, phenoxyethanol, sodium chloride, hexylene glycol, dipotassium phosphate, polyglyceryl-4 caprate, sodium hyaluronate, peumus boldus leaf extract, disodium edta, olea europaea leaf extract/olive leaf extract, myrtrimonium bromide . It is generally regarded as toxic for humans to ingest. It is found in many cosmetics including foundation, sunscreen . It is not in all products so that shouldnt be too difficult. Cosmetic and food grade are not required to be 100% propylene glycol. Of note, it is commonly found in 'pet-safe' anti-freeze products. The FDA approved it to be safe for use in small amounts in 1972 based off of a study done on lab rats. Lactic. Thanks a lot for this information! <> Thanks for catching it. Propylene glycol (also known as 1,2 propanediol) is a relatively small molecule with two alcohol (hydroxyl) groups (-OH). As you said high levels ingested could cause problems? . However, propylene glycol (PG for short) has been the subject of many high-profile news stories as of late, and not for good reason. It is not the main ingredient in antifreeze. , propylene glycol has simply fallen prey to fearmongering marketing strategieslets break down how it happened. Propylene Glycol. Bio-based propylene glycol is safe, not considered a carcinogen or endocrine disrupter, and what you'll find in clean skin care products. When our extremities receive less blood, they get less oxygen, meaning that tissues in the extremities have to resort to producing. Is there a site available that will give me a list of food that DO contain this product or that DO NOT contain PG. There are many different types of glycols, Polyethylene glycol - a term used to describe glycol polymers that have many repeating chains and have. Antifreeze is not a chemical in and of itself, but a role that a chemical or mixture fulfills. 3 0 obj FORMULATIONS with DIPROPYLENE GLYCOL. *Small molecular weight synthetic solvent. you might say. Despite being numerous, these symptoms tell a coherent story: The past presentation of delirium tremens, or severe withdrawal from alcohol, indicates chronic use, and impaired liver functioning wouldnt be out of the question. Description . . In humans, ingesting 786 milligrams per kilogram of bodyweight of pure ethylene glycol can be lethalthats roughly 2 fluid ounces to kill the average adult man, slightly more than a single shots worth if youre a cocktail aficionado. are really pushing the definitions of those terms purportedly documented acute toxicity from consuming Fireball Whiskey. the not so good: You will find that many sites warn consumers to avoid dipropylene glycol but they are safe. IDENTIFICATION PRODUCT NAME: DIPROPYLENE GLYCOL CAS NO: 25265-71-8 . That non sequitur aside, what we do want to reinforce is that if you have to choose between trusting an upstart company or regulatory agency like the FDA, always lean towards the authoritative source. Theres no reason to include PG in a shampoo except as a solvent so the level would be less than 1%, Thanks a lot for this information, its so helpful. That is actually a shame think how useful it would be for diabetes patients if they could get insulin from a cream with no injections. the good: It is used to improve the texture and stability of a formulation. The frustration with hair loss is an overwhelming constant: the hunt for advice, the optimism of trying new products, the ultimate disappointment that follows, and the increased distrust with each product you try. What is dipropylene glycol used for? Thankyou so much for this and other articles which give the scientific facts and not false information designed to scare people off cosmetics. LG`Fh^ME1?N\?=NN>Q1'W/d4,n(R#(KY(1L$Gzq,U5?7/N~v}14Y7:DZRK{d^Mk[M 7-dxP X&w^JFj.X`:BYWWXqoAWPJ44v5xbgC=#vuCa BEu^$2"4eJlPoy^*& J1eT(5t Categories: Compounds, Perfumery Materials SKU: 2021020001929. I dont know about grocery products. Dipropylene Glycol Safety Data Sheet according to Federal Register / Vol. Dipropylene glycol. You may not drink it, but youve certainly heard of it: Fireball Whiskey. you say 25mg=2.5g. But in both cases presented by the medical professionals who submitted the case study for publication in 2021, its worth considering the following self-admission: Although it is reported that Fireball has not contained propylene glycol in any of its products since 2018, the association with severe lactic acidosis needs further research. Because fear sells. As an antifungal and antimicrobial agent, it can be used as a preservative. document.write(''); Shutterstock. This designation means that it's already in many of the foods and cosmetics we use on a daily basis. It is incompatible with strong bases. Among its useful properties is PEGs ability to absorb water, making it commonly used as a laxative by drawing water into the gastrointestinal tract. What is dipropylene glycol methyl ether used for? Other tests have evaluated numerous cosmetic products containing these glycols at concentrations up to 21.4% in various human skin irritation studies. And how do they compare with ProCelinyl? According to a report issued by the World Health Organization, the estimated acceptable daily intake for PG is about 25 mg of propylene glycol per kg body weight. The US Food and Drug Administration (FDA) stated that propylene glycol is "generally recognized as safe," cases of eye and skin irritations, allergies and contact urticaria have been reported in . Among its useful properties is PEGs ability to absorb water, making it commonly used as a laxative by drawing water into the gastrointestinal tract. Perhaps antifreeze was mentioned for because were all familiar with the dangers of pets lapping up any antifreeze thats leaked from the car, or the imagery of toddlers being drawn to its bright colors and mistaking it for a sugary drink.